Gene Expression and Genome Organisation

 
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Nuclear Myosin

Myosin are actin binding proteins found in the cytoplasm and nucleus. We are interested in what myosin proteins do and how they function. We therefore have a strong interest in how these proteins are regulated intrinsically and through other factors.

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Nanoscale organisation

We use single molecule imaging techniques to visualise the nanoscale organisation of myosin and transcription complexes. Through these approaches we can understand how complexes exist within the nucleus.

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Molecular Anchors and Transporters

We propose that myosin uses its ability to act as both a molecular anchor and transporter. We suggest that myosin supports long-range chromatin rearrangements as a transporter and then holds transcription complexes together as an anchor.