Gene Expression and Genome Organisation

Nuclear Myosin

Myosin are actin binding proteins found in the cytoplasm and nucleus. We are interested in what myosin proteins do and how they function. We therefore have a strong interest in how these proteins are regulated intrinsically and through other factors.

Nanoscale organisation

We use single molecule imaging techniques to visualise the nanoscale organisation of myosin and transcription complexes. Through these approaches we can understand how complexes exist within the nucleus.

Molecular Anchors and Transporters

We propose that myosin uses its ability to act as both a molecular anchor and transporter. We suggest that myosin supports long-range chromatin rearrangements as a transporter and then holds transcription complexes together as an anchor.